Audison APK 165 - 2 Ohm Kit Two Way 165 mm

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a b "About us - Our train fleet". Chiltern Railways. Archived from the original on 3 July 2010 . Retrieved 26 August 2008.

In 2012, First Great Western took delivery of Class 180 Adelante units for Cotswold Line services, and three-car Class 150 Sprinter units for Reading to Basingstoke Line services, allowing Class 165 and 166 units to be used to reinforce Thames Valley services. [14] A new depot was built at Aylesbury in 1990/1991 for the maintenance of these trains and has been enlarged since British Rail days, with the addition of a wheel lathe. Light maintenance and refuelling is carried out at Wembley LMD and Tyseley TMD, and units can occasionally be found at Stourbridge LMD. Units are also regularly stabled in the Marylebone station environs, Aylesbury South Sidings and at Banbury, where a further depot is currently under construction at the south end of the station on the western side of the line. The publication of large series of patients with IIP with accompanying pathologic evaluation by experts in lung pathology has provided a clearer picture of the types of histopathologic patterns seen and their relationship to the patient's clinical course and responsiveness to treatment ( 20-23). Chiltern Railways refurbished three car Class 165/0 No. 165032 at London Marylebone. 165039 in revised Chiltern Railways livery at London Marylebone. Each unit was formed of two outer driving motors, with an additional intermediate motor in the 3-car units. The technical description of the formation is DMOCL+MOS+DMOS. Although still listed on the vehicle data sheets at DMCL vehicles, the first-class area has been removed from 2-car 165s operated by GWR. As such these vehicles are now technically DMOSL vehicles. The 3-car units were similarly de-classified, but the first-class accommodation has now been re-instated on these. Individual carriages are numbered as follows: [1]Holden, Alan (5 October 2019). "New timetable for South Wales launched by Great Western Railway". RailAdvent . Retrieved 13 February 2020. It is recommended that the term pattern be added to the IIP designations when referring to the lung biopsy pathologic pattern, to distinguish it from the clinico–radiologic– pathologic diagnosis (e.g., NSIP, DIP, or LIP). These conditions are rare and few physicians have substantial experience with their diagnosis and management. In a small proportion of cases the pathologic diagnosis may need to be revised in the light of an unexpected clinical course, identification of a potential cause for lung fibrosis, or response to treatment. Periodic review should include re-examination of the original lung biopsy and radiologic material in addition to the data from the clinical follow-up. The conversion is done automatically once the nominator, e.g. 165, and the denominator, e.g. 2, have been inserted.

Signal passed at danger and subsequent near miss, Chalfont & Latimer station 21 June 2020" (PDF). Rail Accident Investigation Branch . Retrieved 26 July 2021. The terminology applied to the IIPs has been confusing. Clinicians in different countries have employed varied terms such as idiopathic pulmonary fibrosis (IPF) in the United States and cryptogenic fibrosing alveolitis (CFA) or “lone CFA” (CFA not associated with the presence of collagen vascular disease) ( 2, 3) in the United Kingdom, or idiopathic interstitial pneumonia in Japan ( 4). These represent clinically defined disease entities that historically have included a range of histologic patterns ( 5, 6).Class 165/1 [ edit ] No.165119 at Didcot Parkway. This unit is painted in the original Network SouthEast livery.

The majority of patients recover completely on administration of oral corticosteroids, but a significant number relapse within 1 to 3 mo when the corticosteroids are reduced (usually to below 15 mg/d) or stopped ( 37, 106). Prolonged treatment for 6 mo or longer is advised. A small proportion of patients recovers spontaneously ( 37). Rare cases previously classified as COP are reported to progress to respiratory failure and death. In some of these cases, additional features of diffuse interstitial fibrosis have been present, suggesting an alternative diagnosis including organizing pneumonia superimposed on a UIP lesion (acute exacerbation or accelerated decline of IPF) ( 107, 109-111). a b "First Great Western gets rid of First Class on Reading trains". Rail. Peterborough. 8 September 2015 . Retrieved 7 February 2016. Clinicians have frequently been confused by the descriptions provided in pathology reports, particularly when several patterns are described in a single biopsy.Several developments have prompted a review of the previous classification systems and encouraged the development of a new comprehensive clinical–radiologic and pathologic classification of the IIPs. In late 2015, as part of the rebranding to GWR, the Class 165 fleet had all first-class sections removed to increase capacity. [7] Following the electrification of the Great Western Main Line up to Didcot Parkway, as well as the Reading-Taunton line as far as Newbury, services between London Paddington and Didcot Parkway, as well as between Reading and Newbury, have been operated by new Class 387 electric multiple units, [15] allowing much of the existing Class 165 fleet to move to the Bristol area. Class 165s continue to service the aforementioned branch lines, but no longer run to London Paddington except during peak hours. Temporal heterogeneity pattern: fibroblastic foci with dense fibrosis are inconspicuous or absent—this is especially important in cases with patchy involvement and subpleural or paraseptal distribution

Do patients with histologic UIP who have an atypical CT pattern have different clinical features or clinical course? The true clinical course of confirmed IPF and the impact (if any) of treatment need to be defined.Train derails at Paddington: Services disrupted in and out of station". BBC News. 16 June 2016 . Retrieved 17 June 2016. In more recent publications the term NSIP has evolved from its original use, which was intended to indicate a histologic pattern with a variety of etiologies ( 17). Now it is almost exclusively used to identify a form of IIP ( 18, 20, 21, 35, 36, 40, 90, 94-96). However, the concept of an idiopathic form of NSIP presents a problem for the clinician because there is no recognized and distinctive clinical description for patients presenting with this histologic pattern on lung biopsy. Although these patients have a better prognosis than those with IPF, the clinician does not know this in advance. This improved prognosis has been observed in several studies and appears to correlate with differences in the dominant pathology, whether a cellular or fibrotic pattern of NSIP is present and dominates ( 17, 18, 20, 21, 23, 36, 40, 94, 95). Further subclassification may become necessary, but this remains an issue for further study. It is possible that specific occupational exposures may give rise to this pattern. Thirty-seven Class 165/1 Networker trains were built in 1992 for the Thames line subdivision of Network SouthEast, numbered 165101–137. Like the Chiltern units, both 2-car and 3-car variants were built. Units 165101-117 were delivered as 3-car units, followed by the 2-car units 165118–137. They are re-geared and fitted with bogie yaw dampers to allow a top speed of 90mph (145km/h), more suitable for mainline use.