About this deal
The median lethal dosage of phenibut is 900 mg/kg (milligrams of the agent per kilogram of taker’s body weight). Sulbutiamine is a laboratory-created molecule consisting of two thiamine molecules bound together by a sulfur group. This structure makes sulbutiamine more bioavailable than ordinary thiamine and enhances its ability to cross the blood-brain barrier.
For instance, continuous aerobic exercise such as running releases dopamine within the nucleus accumbens. This as a result causes a state of euphoria through its increased biosynthesis with three other neurochemicals: anadamide, beta-endophins, and phenethylamine. This is what people experience when they say they get a “runner’s high.” To provide another example, euphoria caused by music increase dopamine transmission to the striatum (a part of the forebrain). Sulbutiamine transformation in the body. Molecule at left, sulbutiamine; center molecule, O-isobutyryl-thiamine; white inside red blood cell, thiamine triphosphate. ∗As genuine sulbutiamine was never detected in the blood after oral or intravenous administration, its transformation must be very rapid.
Some people found sulbutiamine made them tired instead of having a positive effect on their fatigue. People have suggested that the antioxidant features may be partially responsible for these effects. Lôo H, Poirier MF, Ollat H, Elatki S. Effects of sulbutiamine (Arcalion 200) on psycho-behavioral inhibition in major depressive episodes. Encephale. 2000
On Reddit, one user described the immediate effects as euphoric. “Wakefulness, energy, confidence, very positive mood. No social inhibitions, enhanced verbal clarity, sharp wit, even a charisma.” Product information on sulbutiamine sold under the brand name Arcalion recommends a daily dosage of 400–600 mg for adults, over a period limited to 4 weeks. [21] One study found that sulbutiamine could play a role as an anti-infective treatment option for those suffering from asthenia. Sulbutiamine”. Foods Herbs & Supplements, Professional, https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=1285. Keep taking sulbutiamine as you have been told by your doctor or other health care provider, even if you feel well.In a 2005 Russian study involving 20 men with erectile dysfunction caused by psychological rather than physical factors, a 30-day course of treatment of sulbutiamine resulted in substantial improvement in 16 of the participants. [18] How It Works Sulbutiamine also has a positive effect on the GABA neurotransmitter system, whereas Thiamine does not. A randomized, double-blind study found that thiamine is necessary for improved mood regulation, primarily when the negative emotions are related to anxiety or depression (5).